Is Pyrrole Disorder Affecting Your Child?

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Pyrrole disorder is becoming more and more prevalent both in children with ADHD and autism and in the general population. It is a little known condition even though its discovery dates back to research into schizophrenia in the 1960s where it was first given the name ‘mauve factor’ and ‘malvaria’

Pyrrole disorder (also known as pyrroluria) is thought to be a genetic disorder of haemoglobin metabolism that produces too much of a molecule called kryptopyrrole which is excreted in the urine. The kryptopyrrole molecule itself is harmless; however it binds with vitamin B6 and zinc, excreting them from the body along with the kryptopyrrole molecule, creating a double deficiency of zinc and B6, the hallmark of pyrrole disorder. There are also changes to fatty acid metabolism which lead to high levels of an omega 6 fatty acid call arachidonic acid. Pyrrole disorder is detected through a urine test costing approximately $100.00

Treatment involves supplementing zinc and B6, both active B6 and standard vitamin B6 are needed. Other minerals such as manganese may also be required along with evening primrose oil.

Vitamin B6 is critical for the production of neurotransmitters and deficiencies can have a profound effect on both mental and physical health. The symptoms are thought to be from the deficiency of B6 and zinc that pyrrole disorder creates. Pyrrole disorder can be triggered by a traumatic event and high stress levels and is often part of the picture for ADHD, Autism, Aspergers, PDD, ODD, Tics, Tourette’s syndrome, depression, schizophrenia and bipolar disorder.

Is Pyrrole Disorder Unique to Autism?

I am starting to see more and more children who are testing positive to pyrrole disorder, both on the spectrum and in the general population. Pyrrole disorder is not a condition specific to Autism nor does it cause Autism. It is thought that pyrrole disorder contributes to the retention of toxins and heavy metals seen in autistic children.

There are many markers of pyrrole disorder and I do notice a definite genetic pattern. Many times if a child is positive then one of the parents will also test positive and notice a significant improvement in symptoms when taking the supplements.

How do I Know if my Child has Pyrrole Disorder?

Below I have listed some common symptoms associated with pyrrole disorder in children.

Sleep problems, particularly taking a long time to fall asleep and waking up easily at night
Sensitivity to the labels on clothes, sensitivity to specific fabrics – eg ‘feels prickly’
Anxiety. (Anxiety can contribute to digestive upsets such as IBS.)
Poor tolerance of stress
Pessimistic outlook
Mood swings, emotional lability
Anger and violence out of proportion to the situation, including rage
Sensory issues
Poor functioning of the digestive system, including poor absorption of nutrients as well as food sensitivities
Low immunity – constantly suffering with coughs and colds
Motion sickness
Reading and learning problems
Poor memory
Slow growth
Delayed puberty
Unpleasant body odour
Stretch marks on skin
Pain in joints and extremities
Sweet fruity breath and body odour
Problems with sugar metabolism

There is often a family history of these factors as well as a history of addictions such as alcoholism, drugs and gambling as well as more severe symptoms such as severe depression and anxiety, schizophrenia, suicide, criminality, seizures and physical debilitation.

To contact Julie Damant, Autism Naturopath call 07 5518 7607 or visit the contact page of this website. Julie can organise the urine test for you.

Further Information on Pyrrole Disorder

Read information compiled by Bill Walsh, Head Scientist at the Pfeiffer Institute on Pyrrole Disorder
Good general information on Pyrrole Disorder
More general information on Pyrrole Disorder
Julie Damant
Autism Naturopath
2/1846 Lower Gold Coast Highway, Suite B, Burleigh Heads. Qld. 4220
07 5518 7607


About the Author:

Julie Damant is the leading Autism Naturopath in Australia, specialising in Autism, ADHD, Aspergers, PDD, learning difficulties, allergies and children’s health. Julie is a degree qualified Naturopath, has completed specialised training with the MINDD Foundation, Michael Sichel and numerous post graduate courses in Naturopathy. “I know improvement is possible, I have seen it, and will continue to see it as families make the changes that are required to help their child. Working together we can, and will make a difference. I look forward to meeting you.”
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